Recent Results

For a reasonably complete and up to date list of my publication please go here.

Shear thickening of dense suspensions: The role of friction

A new paper was published in Physics of Fluids by Vishnu Sivadasan, Eric Lorenz, Alfons G. Hoekstra, and Daniel BonnRead further details at https://doi.org/10.1063/1.5121536.

 

Location-Specific Comparison Between a 3D In-Stent Restenosis Model and Micro-CT and Histology Data from Porcine In Vivo Experiments

P. S. Zun, A. J. Narracott, C. Chiastra, J. Gunn and A. G. Hoekstra have published a paper presenting a detailed location-specific validation methodology for in silico restenosis models. https://link.springer.com/article/10.1007/s13239-019-00431-4

 

A particle‑based model for endothelial cell migration under flow conditions

P. S. Zun, A. J. Narracott, P. C. Evans, B. J. M. van Rooij and A. G. Hoekstra have published an article on modelling endothelial cell migration under flow conditions.
https://link.springer.com/article/10.1007%2Fs10237-019-01239-w

 

Identifying the start of a platelet aggregate by the shear rate and the cell-depleted layer

B. J. M. van Rooij , G. Závodszky , V. W. Azizi Tarksalooyeh and A. G. Hoekstra published an article on platelet transport under high shear rate conditions. https://royalsocietypublishing.org/doi/10.1098/rsif.2019.0148

 

Semi-intrusive Uncertainty Propagation for multiscale models

Anna Nikishova and Alfons G. Hoekstra have published an article on semi-intrusive Uncertainty Propagation for multiscale models in the Journal of Computational Science: https://doi.org/10.1016/j.jocs.2019.06.007.

Red blood cell and platelet diffusivity and margination in the presence of cross-stream gradients in blood flows

Gábor Závodszky, Britt van Rooij, Ben Czaja, Victor Azizi, David de Kanter, and Alfons G. Hoekstra in Physics of Fluids. The article was chosen as the front cover story for the issue. Read more here: https://aip.scitation.org/doi/10.1063/1.5085881

 

Cell-resolved blood flow simulations of saccular aneurysms

Benjamin Czaja, Gabor Zavodszky, Victor Azizi, and Alfons Hoekstra was published in the Journal of the Royal Open society Interface. Read more here: http://rsif.royalsocietypublishing.org/content/15/146/20180485

 

Patterns for High Performance Multiscale Computing

S.Alowayyed, T. Piontek, J.L.Suterd, O.Hoenene, D.Groen, O.Luke, B.Bosak, P.Kopta, K.Kurowski, O.Perks, K.Brabazon, V.Jancauskas, D.Coster, P.V.Coveney, A.G.Hoekstra was recently published in Future Generation Computer Systems. For more details visit: https://www.sciencedirect.com/science/article/pii/S0167739X18300669

 

Numerical Investigation of the Effects of Red Blood Cell Cytoplasmic Viscosity

Mike de Haan, Gábor Závodszky, Victor Azizi, and Alfons Hoekstra was recently published in the Special Issue “Development and Applications of Kinetic Solvers for Complex Flows” of Applied Sciences. For more details visit: http://www.mdpi.com/2076-3417/8/9/1616

 

Uncertainty Quantification of a Multiscale Model for In-Stent Restenosis

Anna Nikishova et. al recently published a paper on “Uncertainty Quantification of a multiscale model for In-Stent Restenosis” in a special issue on “Verification, Validation and Uncertainty Quantification of Cardiovascular Models” in Cardiovascular Engineering and Technology (https://doi.org/10.1007/s13239-018-00372-4).

 

The Virtual Physiological Human – a ‘digital twin’ for patients

On 18 December 2017, Interface Focus published a themed issue ‘The virtual physiological human: translating the VPH to the clinic’ organised by Alfons Hoekstra, Frank Gijsen, Ed van Bavel, Marie Siebes and Liesbet Geris. In a recent interview released for the launch of the special issue, Alfons Hoekstra (VPH2016 conference chair) explains his vision of the VPH: read the full interview here. For more information visit this link.

 

Load balancing of parallel cell-based blood flow simulations

Saad Alowayyed, Gábor Závodszky, Victor Azizi, and Alfons Hoekstra was recently published in Journal of Computational Science. For more details please see http://www.sciencedirect.com/science/article/pii/S1877750317302788.

 

Multiscale Computing in the Exascale Era

The research article on “Multiscale Computing in the Exascale Era” by Saad Alowayyed, Derek Groen, Peter V. Coveney, and Alfons G. Hoekstra was recently published in Journal of Computational Science. For more details please see http://journal.frontiersin.org/article/10.3389/fphys.2017.00563/full 

 

Revisiting the use of the immersed-boundary lattice-Boltzmann method for simulations of suspended particles

The research article on “Revisiting the use of the immersed-boundary lattice-Boltzmann method for simulations of suspended particles” by L. Mountrakis, E. Lorenz, and A. G. Hoekstra was recently published in Physical Review E. For more details please see https://journals.aps.org/pre/pdf/10.1103/PhysRevE.96.013302

 

Towards the virtual artery: a multiscale model for vascular physiology at the physics–chemistry–biology interface

This discussion paper introduces the concept of the Virtual Artery as a multiscale model for arterial physiology and pathologies at the physics–chemistry–biology (PCB) interface. The cellular level is identified as the mesoscopic level, and we argue that by coupling cell-based models with other relevant models on the macro- and microscale, a versatile model of arterial health and disease can be composed. This  concept of models at the PCB interface could or perhaps should become a powerful paradigm, not only as in our case for studying physiology, but also for many other systems that have such PCB interfaces. DOI: 10.1098/rsta.2016.0146

 

Scaling of shear-induced diffusion and clustering in a blood-like suspension

Lampros Mountrakis et. al published a paper in Europhysics Letters where they demonstrate that shear-induced diffusion of red blood cells (in a two-dimensional model system) does not follow the established linear scaling with shear rate for high hematocrits.